This type of blitz can be a challenge if you do not have your blocking rules to account for all the players. In an even man front defense, if you have one guard first start with the inside gap and the center start with gap away, then you at least have a helmet on any blitzing linebacker. If two backers come in either A gap, you will have them blocked.
In a 50 defense, the center may be occupied with the nose so only the guard on the play side can block the inside gap to begin with, but you may find that you need to have the off-side guard have an inside gap rule also.
As far as plays you can use to attack this type of blitz, you can start with a quick trap on one of the linebackers. The center would block the other backer, and the guard would pull and short trap the other backer who is blitzing across the line of scrimmage.
Moving to the outside, you can run an option, pitch or quick toss to get the ball away from the blitzing backers and in position to make some yards.
Passing can be another challenge in setting up your protection. One way is to block the five offensive linemen right or left and have a back or tight end stay in and block on the side away from the offensive line's block. This type of blocking can be used with a movement pass [roll out - sprint] or with a drop-back pass.
Another way is to run a play-action pass and have one of the backs faking the run picking up the blitzing backer in the A gap to the side of the fake. The center will then block back and pick up the blitzing backer on the other side leaving the guards and tackles free to block the defensive linemen as the quarterback sets up to pass.
Your quick three-step drop passing can also be effective, where the entire line blocks inside on the snap and both backs divide to block to the outside. Here you can throw a four-yard hitch, slant or quick out to either wide receiver or a look in pass to the tight end. Make sure the quarterback knows to get the ball released right away.